Recent advances in our understanding of the mechanisms of late lung development and bronchopulmonary dysplasia
DE Surate Solaligue… - … of Physiology-Lung …, 2017 - journals.physiology.org
The objective of lung development is to generate an organ of gas exchange that provides
both a thin gas diffusion barrier and a large gas diffusion surface area, which concomitantly …
both a thin gas diffusion barrier and a large gas diffusion surface area, which concomitantly …
PPARγ links BMP2 and TGFβ1 pathways in vascular smooth muscle cells, regulating cell proliferation and glucose metabolism
BMP2 and TGFβ1 are functional antagonists of pathological remodeling in the arteries,
heart, and lung; however, the mechanisms in VSMCs, and their disturbance in pulmonary …
heart, and lung; however, the mechanisms in VSMCs, and their disturbance in pulmonary …
Phenotypes in pulmonary hypertension
The clinical classification of pulmonary hypertension (PH) has guided diagnosis and
treatment of patients with PH for several decades. Discoveries relating to underlying …
treatment of patients with PH for several decades. Discoveries relating to underlying …
Pulmonary hypertension secondary to pulmonary fibrosis: clinical data, histopathology and molecular insights
G Ruffenach, J Hong, M Vaillancourt, L Medzikovic… - Respiratory …, 2020 - Springer
Pulmonary hypertension (PH) develo** secondarily in pulmonary fibrosis (PF) patients
(PF-PH) is a frequent co-morbidity. The high prevalence of PH in PF patients is very …
(PF-PH) is a frequent co-morbidity. The high prevalence of PH in PF patients is very …
Emerging mechanisms of pulmonary vasoconstriction in SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) and potential therapeutic targets
The 1918 influenza killed approximately 50 million people in a few short years, and now, the
world is facing another pandemic. In December 2019, a novel coronavirus named severe …
world is facing another pandemic. In December 2019, a novel coronavirus named severe …
[HTML][HTML] Lipid nanoparticle-mediated mRNA delivery in lung fibrosis
Abstract mRNA delivery enables the specific synthesis of proteins with therapeutic potential,
representing a powerful strategy in diseases lacking efficacious pharmacotherapies …
representing a powerful strategy in diseases lacking efficacious pharmacotherapies …
Impairment of the NKT–STAT1–CXCL9 axis contributes to vessel fibrosis in pulmonary hypertension caused by lung fibrosis
K Jandl, LM Marsh, AC Mutgan, S Crnkovic… - American Journal of …, 2022 - atsjournals.org
Rationale: Pulmonary hypertension (PH) is a common, severe comorbidity in interstitial lung
diseases such as pulmonary fibrosis (PF), and it has limited treatment options. Excessive …
diseases such as pulmonary fibrosis (PF), and it has limited treatment options. Excessive …
Consequences of BMPR2 deficiency in the pulmonary vasculature and beyond: contributions to pulmonary arterial hypertension
A Andruska, E Spiekerkoetter - International journal of molecular sciences, 2018 - mdpi.com
Since its association with familial pulmonary arterial hypertension (PAH) in 2000, Bone
Morphogenetic Protein Receptor II (BMPR2) and its related signaling pathway have become …
Morphogenetic Protein Receptor II (BMPR2) and its related signaling pathway have become …
BMP type II receptor as a therapeutic target in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a chronic disease characterized by a progressive
elevation in mean pulmonary arterial pressure. This occurs due to abnormal remodeling of …
elevation in mean pulmonary arterial pressure. This occurs due to abnormal remodeling of …
The role of circular RNAs in pulmonary hypertension
Circular RNAs (circRNAs) are endogenous, covalently circularised, non-protein-coding
RNAs generated from back-splicing. Most circRNAs are very stable, highly conserved, and …
RNAs generated from back-splicing. Most circRNAs are very stable, highly conserved, and …