Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …

Dermatomyositis (DM) is an idiopathic inflammatory myopathy that is clinically
heterogeneous and that can be difficult to diagnose. Cutaneous manifestations sometimes …

The type I interferon pathway has been implicated in the pathogenesis of a number of
rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis …

Objective This open‐label 12‐week study was conducted to evaluate the efficacy and safety
of tofacitinib, a JAK inhibitor, in treatment‐refractory active dermatomyositis (DM). Methods …

Investigations of patients with systemic lupus erythematosus have applied insights from
studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator …

Dermatomyositis is an acquired auto-immune disease characterized by skin lesions and
muscle-specific pathological features such as perifascicular muscle fibre atrophy and …

Objective Activation of the type 1 interferon (IFN1) pathway is a prominent feature of
dermatomyositis (DM) muscle and may play a role in the pathogenesis of this disease …

Polymyositis and dermatomyositis are inflammatory myopathies that differ in their clinical
features, histopathology, response to treatment, and prognosis. Although their clinical …

Autoimmune diseases develop as a result of chronic inflammation owing to interactions
between genes and the environment. However, the mechanisms by which autoimmune …

The classification of idiopathic inflammatory myopathies (IIM) is based on clinical,
serological and histological criteria. The identification of myositis‐specific antibodies has …