Metalloproteinases and their inhibitors: potential for the development of new therapeutics
The metalloproteinase (MP) family of zinc-dependent proteases, including matrix
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …
Missing the target: matrix metalloproteinase antitargets in inflammation and cancer
Matrix metalloproteinases (MMPs) are reputed to cause the inflammatory tissue destruction
characterizing chronic inflammatory diseases and to degrade basement membrane …
characterizing chronic inflammatory diseases and to degrade basement membrane …
Therapeutic potential of matrix metalloproteinase inhibition in breast cancer
ES Radisky… - Journal of cellular …, 2017 - Wiley Online Library
Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that cleave nearly all
components of the extracellular matrix as well as many other soluble and cell‐associated …
components of the extracellular matrix as well as many other soluble and cell‐associated …
Selective inhibitors of medium-size S1′ pocket matrix metalloproteinases: a step** stone of future drug discovery
Among various matrix metalloproteinases (MMPs), MMPs having medium-size S1′ pockets
are established as promising biomolecular targets for executing crucial roles in cancer …
are established as promising biomolecular targets for executing crucial roles in cancer …
[HTML][HTML] Matrix metalloproteinases as breast cancer drivers and therapeutic targets
Members of the matrix metalloproteinase (MMP) family have been identified as poor
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …
Extracellular matrix: emerging roles and potential therapeutic targets for breast cancer
Y Zhao, X Zheng, Y Zheng, Y Chen, W Fei… - Frontiers in …, 2021 - frontiersin.org
Increasing evidence shows that the extracellular matrix (ECM) is an important regulator of
breast cancer (BC). The ECM comprises of highly variable and dynamic components …
breast cancer (BC). The ECM comprises of highly variable and dynamic components …
Matrix metalloproteinases as new targets in Alzheimer's disease: Opportunities and challenges
P Zipfel, C Rochais, K Baranger, S Rivera… - Journal of Medicinal …, 2020 - ACS Publications
Although matrix metalloproteinases (MMPs) are implicated in the regulation of numerous
physiological processes, evidence of their pathological roles have also been obtained in the …
physiological processes, evidence of their pathological roles have also been obtained in the …
Assessing structural insights into in-house arylsulfonyl L-(+) glutamine MMP-2 inhibitors as promising anticancer agents through structure-based computational …
ABSTRACT MMP-2 is potentially contributing to several cancer progressions including
leukaemias. Therefore, considering MMP-2 as a promising target, novel anticancer …
leukaemias. Therefore, considering MMP-2 as a promising target, novel anticancer …
C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease
Controlled macrophage differentiation and activation in the initiation and resolution of
inflammation is crucial for averting progression to chronic inflammatory and autoimmune …
inflammation is crucial for averting progression to chronic inflammatory and autoimmune …
[HTML][HTML] Regulation and involvement of matrix metalloproteinases in vascular diseases
M Amin, S Pushpakumar, N Muradashvili… - Frontiers in …, 2016 - ncbi.nlm.nih.gov
Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases whose
main function is to degrade and deposit structural proteins within the extracellular matrix …
main function is to degrade and deposit structural proteins within the extracellular matrix …