ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

CONCLUSION The notion that inflammation is the net resultant of pro and contra
inflammatory pathways (Fauve, 1980) is well illustrated by the dual role of neutrophils which …

Researchers have recently made advances in defining the pathogenesis of gout, including
elucidating its risk factors and tracing the molecular mechanisms of renal urate transport and …

Purpose The aims of this article were to systematically review the literature about the
mechanism of action of colchicine in the multimodal pathology of acute inflammation …

The concept of the CNS as an immune-privileged organ has led to a common
misunderstanding that it is not an active immunological organ, guarded from its …

Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show
that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell …

Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation
caused by precipitation of monosodium urate crystals (MSU) in the joint. Recent studies …

The three isoforms of apolipoprotein E (APOE2, APOE3, and APOE4) only differ in two
amino acid positions but exert quite different immunomodulatory effects. The underlying …

New light has been shed on the mechanisms of action of colchicine in crystal-associated
arthropathies. Colchicine, long used to treat gout, arrests microtubule assembly and inhibits …

The clinical manifestations of gout are due to interactions between monosodium urate
(MSU) crystals and local tissues. This review article outlines recent advances in the …