Microorganisms including bacteria, fungi, viruses, protists and archaea live as communities
in complex and contiguous environments. They engage in numerous inter-and intra …

Understanding cellular heterogeneity is the holy grail of biology and medicine. Cells
harboring identical genomes show a wide variety of behaviors in multicellular organisms …

Exercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) and
prediabetes, however, how exercise and diet interventions impact gut microbiota in patients …

We present dyngen, a multi-modal simulation engine for studying dynamic cellular
processes at single-cell resolution. dyngen is more flexible than current single-cell …

Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its
underlying mechanisms remain elusive. Here we reconstruct a trajectory of cardiomyocyte …

Reliable map** of system-level individual differences is a critical first step toward
precision medicine for complex disorders such as schizophrenia. Disrupted structural …

Single-cell RNA sequencing (scRNA-seq) is able to give an insight into the gene–gene
associations or transcriptional networks among cell populations based on the sequencing of …

Network biology is an interdisciplinary field bridging computational and biological sciences
that has proved pivotal in advancing the understanding of cellular functions and diseases …

Biological systems are driven by intricate interactions among molecules. Many methods
have been developed that draw on large numbers of expression samples to infer …

Spatially resolved transcriptomics (SRT) technology enables us to gain novel insights into
tissue architecture and cell development, especially in tumors. However, lacking …