Technological innovations in photochemistry for organic synthesis: flow chemistry, high-throughput experimentation, scale-up, and photoelectrochemistry

L Buglioni, F Raymenants, A Slattery… - Chemical …, 2021 - ACS Publications
Photoinduced chemical transformations have received in recent years a tremendous amount
of attention, providing a plethora of opportunities to synthetic organic chemists. However …

Photocatalysis in the life science industry

L Candish, KD Collins, GC Cook, JJ Douglas… - Chemical …, 2021 - ACS Publications
In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …

Exploring visible light for carbon–nitrogen and carbon–oxygen bond formation via nickel catalysis

S Zhu, H Li, Y Li, Z Huang, L Chu - Organic Chemistry Frontiers, 2023 - pubs.rsc.org
Heteroatom-containing motifs are one of the most privileged scaffolds for pharmaceuticals,
agrochemicals, and functional materials. Transition-metal-catalyzed carbon–heteroatom …

Light-Promoted Ni-Catalyzed Cross-Coupling of Aryl Chlorides with Hydrazides: Application to the Synthesis of Rizatriptan

F Li, W **ong, G Song, Y Yan, G Li, C Wang… - Organic …, 2023 - ACS Publications
A general and highly efficient photochemical C–N coupling reaction of challenging (hetero)
aryl chlorides with hydrazides is reported. Catalyzed by a Ni (II)–bipyridine complex, this …

Continuous flow synthesis enabling reaction discovery

AI Alfano, J García-Lacuna, OM Griffiths, SV Ley… - Chemical …, 2024 - pubs.rsc.org
This article defines the role that continuous flow chemistry can have in new reaction
discovery, thereby creating molecular assembly opportunities beyond our current …

Flow photochemistry—from microreactors to large-scale processing

M Zhang, P Roth - Current Opinion in Chemical Engineering, 2023 - Elsevier
Miniaturized continuous photoreactors have been recently receiving an increasing amount
of attention from researchers both in academia and in industry. The upscaling of flow …

Recent advances in photoredox catalytic transformations by using continuous-flow technology

X Yuan, HB Fan, J Liu, LZ Qin, J Wang, X Duan… - Chinese Journal of …, 2023 - Elsevier
Photoredox catalysis is regarded as an economically appealing method for highly efficient
and sustainable chemical syntheses. Nevertheless, numerous recent studies have revealed …

Synthesis of N‐Aryl‐ and N‐Alkenylhydrazides through C(sp2)−N Bond Construction

J Lei, W **e, J Li, Y Wu, X **e - European Journal of Organic …, 2021 - Wiley Online Library
N‐Aryl‐and N‐alkenylhydrazides, which include a C (sp2)‐N− N motif, have attracted
considerable attention not only in biologically active molecules but also because of their …

FeO(OH)@C‐Catalyzed Selective Hydrazine Substitution of p‐Nitro‐Aryl Fluorides and their Application for the Synthesis of Phthalazinones

D Li, W Zhang, L Zhu, SF Yin, N Kambe… - ChemistryOpen, 2022 - Wiley Online Library
An efficient hydrazine substitution of p‐nitro‐aryl fluorides with hydrazine hydrates catalyzed
by FeO (OH)@ C nanoparticles is described. This hydrazine substitutions of p‐nitro‐aryl …

Progress Toward the Enantioselective Synthesis of Corynoxine and Relevant Analogues Design, Synthesis, and Investigation of Novel Mechanism-Based Inactivators …

AN Devitt - 2023 - search.proquest.com
Natural products and natural product analogs play a key role in drug discovery. Natural
products are a broad range of small molecules, from basic building blocks like amino acids …