Next generation sequencing is in the process of evolving from a technology used for
research purposes to one which is applied in clinical diagnostics. Recently introduced high …

B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

Amplicon-based next-generation sequencing (NGS) of immunoglobulin (IG) and T-cell
receptor (TR) gene rearrangements for clonality assessment, marker identification and …

Lymphomas are heterogeneous tumors with striking genetic diversity and variable outcomes
even within pathologic diagnoses. Treatment response assessment relies on radiologic and …

Assessment of clonality, marker identification and measurement of minimal residual disease
(MRD) of immunoglobulin (IG) and T cell receptor (TR) gene rearrangements in lymphoid …

Current diagnostic standards for lymphoproliferative disorders include multiple tests for
detection of clonal immunoglobulin (IG) and/or T-cell receptor (TCR) rearrangements …

Abstract Purpose of Review Over the last decade, the development of effective treatment
approaches for multiple myeloma (MM) has been associated with higher response rates and …

The assessment of the cancer mutational profile is crucial for patient management,
stratification, and therapeutic decisions. At present, in hematological malignancies with a …

Minimal residual disease (MRD) has been increasingly investigated in mantle cell
lymphoma (MCL), including for individual therapeutic stratification and pre-emptive …

Objective To comparatively analyse the aberrant affinity maturation of the antinuclear and
rheumatoid factor (RF) B cell repertoires in blood and tissues of patients with Sjögren's …