Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Müller glia are the major glial component of the retina. They are one of the last retinal cell
types to be born during development, and they function to maintain retinal homeostasis and …

We present SCENIC, a computational method for simultaneous gene regulatory network
reconstruction and cell-state identification from single-cell RNA-seq data (http://scenic …

Aberrant hepatocyte Notch activity is critical to the development of nonalcoholic
steatohepatitis (NASH)–induced liver fibrosis, but mechanisms underlying Notch reactivation …

In humans, various genetic defects or age-related diseases, such as diabetic retinopathies,
glaucoma, and macular degeneration, cause the death of retinal neurons and profound …

Neural progenitors of the vertebrate CNS are defined by generic cellular characteristics,
including their pseudoepithelial morphology and their ability to divide and differentiate …

Gene regulatory networks (GRNs), consisting of transcription factors and their target sites,
control neurogenesis and cell-fate specification in the develo** central nervous system. In …

The large number of candidate genes made available by comprehensive genome analysis
requires that relatively rapid techniques for the study of function be developed. Here, we …

Notch signaling dictates cell fate and critically influences cell proliferation, differentiation,
and apoptosis in metazoans. Multiple factors at each step—ligands, receptors, signal …

OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the
pMN domain of the spinal cord, which sequentially generates motoneurons and …