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Fluorescent Flippers: Small‐Molecule Probes to Image Membrane Tension in Living Systems
Flipper probes have been introduced as small molecule fluorophores to image physical
forces, that is, membrane tension in living systems. Their emergence over one decade is …
forces, that is, membrane tension in living systems. Their emergence over one decade is …
Stimuli‐responsive natural proteins and their applications
Natural proteins are essential biomacromolecules that fulfill versatile functions in the living
organism, such as their usage as cytoskeleton, nutriment transporter, homeostasis …
organism, such as their usage as cytoskeleton, nutriment transporter, homeostasis …
HydroFlipper membrane tension probes: imaging membrane hydration and mechanical compression simultaneously in living cells
J García-Calvo, J López-Andarias, J Maillard… - Chemical …, 2022 - pubs.rsc.org
HydroFlippers are introduced as the first fluorescent membrane tension probes that report
simultaneously on membrane compression and hydration. The probe design is centered …
simultaneously on membrane compression and hydration. The probe design is centered …
A tethered ligand assay to probe SARS-CoV-2: ACE2 interactions
SARS-CoV-2 infections are initiated by attachment of the viral receptor-binding domain
(RBD) to angiotensin-converting enzyme-2 (ACE2) on human host cells. This critical first …
(RBD) to angiotensin-converting enzyme-2 (ACE2) on human host cells. This critical first …
Engineering photoresponsive ligand tethers for mechanical regulation of stem cells
Regulating stem cell functions by precisely controlling the nanoscale presentation of
bioactive ligands has a substantial impact on tissue engineering and regenerative medicine …
bioactive ligands has a substantial impact on tissue engineering and regenerative medicine …
Histidine-specific bioconjugation for single-molecule force spectroscopy
Atomic force microscopy (AFM) based single-molecule force spectroscopy (SMFS) is a
powerful tool to study the mechanical properties of proteins. In these experiments, site …
powerful tool to study the mechanical properties of proteins. In these experiments, site …
Fluorescent membrane tension probes for early endosomes
F Piazzolla, V Mercier, L Assies, N Sakai… - Angewandte …, 2021 - Wiley Online Library
Fluorescent flipper probes have been introduced recently to image membrane tension in live
cells, and strategies to target these probes to specific membranes are emerging. In this …
cells, and strategies to target these probes to specific membranes are emerging. In this …
Water-soluble red fluorescent protein dimers for hypoxic two-photon photodynamic therapy
W Feng, Y Qian - Journal of Materials Chemistry B, 2024 - pubs.rsc.org
In this study, two water-soluble red fluorescent protein (RFP) dimers, FP2R′ and FP2R′′,
were synthesized by linking two phenothiazine-based RFP chromophore analogues through …
were synthesized by linking two phenothiazine-based RFP chromophore analogues through …
Multiple Photoisomerization Pathways of the Green Fluorescent Protein Chromophore in a Reversibly Photoswitchable Fluorescent Protein: Insights from Quantum …
YH Zhu, XX Liu, Q Fang, XY Liu… - The Journal of Physical …, 2023 - ACS Publications
Herein, we have employed a combined CASPT2//CASSCF approach within the quantum
mechanics/molecular mechanics (QM/MM) framework to explore the early time …
mechanics/molecular mechanics (QM/MM) framework to explore the early time …
Lights up on organelles: Optogenetic tools to control subcellular structure and organization
Since the neurobiological inception of optogenetics, light‐controlled molecular perturbations
have been applied in many scientific disciplines to both manipulate and observe cellular …
have been applied in many scientific disciplines to both manipulate and observe cellular …