R-loops involve in various biological processes under human normal physiological
conditions. Disruption of R-loops can lead to disease onset and affect the progression of …

Stem cells are the fundamental drivers of growth during development and adult organ
homeostasis. The properties that define stem cells–self-renewal and differentiation–are …

R-loops, three-stranded nucleic acid structures composed of RNA-DNA hybrids, are
increasingly recognized as central regulators of genomic stability and transcription. These …

Pineoblastoma (PB) is a rare yet lethal pediatric brain cancer of the pineal gland, a small
endocrine organ that secretes melatonin to regulate the circadian rhythm. For PB patients≤ …

Simple Summary When oncogenes, which are genes that can cause cancer, become active,
they disrupt normal cell processes, especially DNA replication. This disruption is known as …

This study investigates the communication between skin cells, specifically melanocytes,
keratinocytes, and fibroblasts, which is crucial for the process of melanin production known …

Abstract The 12th Tuscany Retreat on Cancer Research and Apoptosis was held on August
19–26, 2023. The biennial retreat aims to bring together scientists who advance research in …

Kaposi's sarcoma-associated herpesvirus (KSHV) was first identified in 1994 as the
causative agent of the endothelial cell neoplasm, Kaposi's sarcoma (KS). Soon after its …

R-loop accumulation has emerged as a critical factor that induces DNA damage and
compromises genome integrity. However, the regulatory mechanisms governing R-loop …