Since the days of Sanger sequencing, next-generation sequencing technologies have
significantly evolved to provide increased data output, efficiencies, and applications. These …

With the total amount of worldwide data skyrocketing, the global data storage demand is
predicted to grow to 1.75× 1014 GB by 2025. Traditional storage methods have difficulties …

Large serine recombinases (LSRs) are DNA integrases that facilitate the site-specific
integration of mobile genetic elements into bacterial genomes. Only a few LSRs, such as …

Over the past decade, long-read, single-molecule DNA sequencing technologies have
emerged as powerful players in genomics. With the ability to generate reads tens to …

Abstract Combined Annotation-Dependent Depletion (CADD) is a widely used measure of
variant deleteriousness that can effectively prioritize causal variants in genetic analyses …

Nearly all genetic variants that influence disease risk have human-specific origins; however,
the systems they influence have ancient roots that often trace back to evolutionary events …

High throughput DNA sequencing methodology (next generation sequencing; NGS) has
rapidly evolved over the past 15 years and new methods are continually being …

Class 2 CRISPR-Cas systems endow microbes with diverse mechanisms for adaptive
immunity. Here, we analyzed prokaryotic genome and metagenome sequences to identify …

Molecular data storage is an attractive alternative for dense and durable information storage,
which is sorely needed to deal with the growing gap between information production and the …

Harnessing the process of natural selection to obtain and understand new microbial
phenotypes has become increasingly possible due to advances in culturing techniques …