Pioneer transcription factors: establishing competence for gene expression
Transcription factors are adaptor molecules that detect regulatory sequences in the DNA
and target the assembly of protein complexes that control gene expression. Yet much of the …
and target the assembly of protein complexes that control gene expression. Yet much of the …
Membrane and nuclear estrogen receptor alpha actions: from tissue specificity to medical implications
JF Arnal, F Lenfant, R Metivier, G Flouriot… - Physiological …, 2017 - journals.physiology.org
Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …
A high-resolution map of the three-dimensional chromatin interactome in human cells
A large number of cis-regulatory sequences have been annotated in the human genome,,
but defining their target genes remains a challenge. One strategy is to identify the long …
but defining their target genes remains a challenge. One strategy is to identify the long …
[HTML][HTML] Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation
Higher-order chromosomal organization for transcription regulation is poorly understood in
eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag …
eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag …
Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma
Melanoma cells can switch between a melanocytic and a mesenchymal-like state. Scattered
evidence indicates that additional intermediate state (s) may exist. Here, to search for such …
evidence indicates that additional intermediate state (s) may exist. Here, to search for such …
LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer
Tamoxifen, an estrogen receptor (ER) antagonist, is the mainstay treatment of breast cancer
and the development of resistance represents a major obstacle for a cure. Although long …
and the development of resistance represents a major obstacle for a cure. Although long …
Estrogen signaling in endometrial cancer: a key oncogenic pathway with several open questions
Endometrial cancer is the most common gynecological cancer in the developed world, and it
is one of the few cancer types that is becoming more prevalent and leading to more deaths …
is one of the few cancer types that is becoming more prevalent and leading to more deaths …
Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape
We describe protein interaction quantitation (PIQ), a computational method for modeling the
magnitude and shape of genome-wide DNase I hypersensitivity profiles to identify …
magnitude and shape of genome-wide DNase I hypersensitivity profiles to identify …
Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits
DNA variants (SNPs) that predispose to common traits often localize within noncoding
regulatory elements such as enhancers. Moreover, loci identified by genome-wide …
regulatory elements such as enhancers. Moreover, loci identified by genome-wide …
GATA3 acts upstream of FOXA1 in mediating ESR1 binding by sha** enhancer accessibility
Estrogen receptor (ESR1) drives growth in the majority of human breast cancers by binding
to regulatory elements and inducing transcription events that promote tumor growth …
to regulatory elements and inducing transcription events that promote tumor growth …