Internal dynamics and protein–matrix coupling in trehalose-coated proteins

L Cordone, G Cottone, S Giuffrida, G Palazzo… - … Et Biophysica Acta (BBA …, 2005 - Elsevier
We review recent studies on the role played by non-liquid, water-containing matrices on the
dynamics and structure of embedded proteins. Two proteins were studied, in water …

Thermodynamic and dynamic factors involved in the stability of native protein structure in amorphous solids in relation to levels of hydration

JJ Hill, EY Shalaev, G Zografi - Journal of pharmaceutical sciences, 2005 - Elsevier
The internal, dynamical fluctuations of protein molecules exhibit many of the features typical
of polymeric and bulk small molecule glass forming systems. The response of a protein's …

Beneficial effects of trehalose and gentiobiose on human sperm cryopreservation

D Gholami, M Sharafi, V Esmaeili, T Nadri, L Alaei… - Plos one, 2023 - journals.plos.org
The protection of human sperm during cryopreservation is of great importance to infertility.
Recent studies have shown that this area is still a long way from its ultimate aim of …

How do trehalose, maltose, and sucrose influence some structural and dynamical properties of lysozyme? Insight from molecular dynamics simulations

A Lerbret, P Bordat, F Affouard, A Hédoux… - The Journal of …, 2007 - ACS Publications
The influence of three well-known disaccharides, namely, trehalose, maltose, and sucrose,
on some structural and dynamical properties of lysozyme has been investigated by means of …

Interaction of the sugars trehalose, maltose and glucose with a phospholipid bilayer: a comparative molecular dynamics study

CS Pereira, PH Hünenberger - The Journal of Physical Chemistry …, 2006 - ACS Publications
Molecular dynamics simulations are used to investigate the interaction of the sugars
trehalose, maltose, and glucose with a phospholipid bilayer at atomic resolution …

Structural and dynamical characteristics of trehalose and sucrose matrices at different hydration levels as probed by FTIR and high-field EPR

M Malferrari, A Nalepa, G Venturoli, F Francia… - Physical Chemistry …, 2014 - pubs.rsc.org
Some organisms can survive complete dehydration and high temperatures by adopting an
anhydrobiotic state in which the intracellular medium contains large amounts of …

Mechanism of trehalose-induced protein stabilization from neutron scattering and modeling

C Olsson, S Genheden, V García Sakai… - The Journal of …, 2019 - ACS Publications
The sugar molecule trehalose has been proven to be an excellent stabilizing cosolute for the
preservation of biological materials. However, the stabilizing mechanism of trehalose has …

Proteins in saccharides matrices and the trehalose peculiarity: Biochemical and biophysical properties

L Cordone, G Cottone, A Cupane… - Current Organic …, 2015 - ingentaconnect.com
Immobilization of proteins and other biomolecules in saccharide matrices leads to a series of
peculiar properties that are relevant from the point of view of both biochemistry and …

Role of residual water hydrogen bonding in sugar/water/biomolecule systems: a possibleexplanation for trehalose peculiarity

L Cordone, G Cottone, S Giuffrida - Journal of Physics …, 2007 - iopscience.iop.org
We report on the set of experimental and simulative evidences which enabled us to suggest
how biological structures embedded in a non-liquid water–saccharide solvent are anchored …

[HTML][HTML] Trehalose matrix effects on charge-recombination kinetics in Photosystem I of oxygenic photosynthesis at different dehydration levels

M Malferrari, A Savitsky, MD Mamedov… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Matrix effects on long-range electron transfer were studied in cyanobacterial Photosystem I
(PS I) complexes, embedded into trehalose glasses at different hydration levels. W-band …