ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Alzheimer's disease is the most common cause of dementia worldwide, with the prevalence
continuing to grow in part because of the aging world population. This neurodegenerative …

Background/objectives Physical activity (PA) protects against a wide range of diseases.
Habitual PA appears to be heritable, motivating the search for specific genetic variants that …

Highlights•Physical activity is an effective method of capitalizing on brain plasticity.•Some
brain areas and cognitive domains are more consistently influenced by physical activity than …

Physical activity (PA) is known to maintain and improve neurocognitive health. However,
there is still a poor understanding of the mechanisms by which PA exerts its effects on the …

Abstract Purpose of Review The aim of this review is to summarize current conceptual
models of cognitive reserve (CR) and related concepts and to discuss evidence for these …

This report describes a novel, comprehensive, and personalized therapeutic program that is
based on the underlying pathogenesis of Alzheimer's disease, and which involves multiple …

Objective To determine efficacy of aerobic exercise for cognitive function in younger healthy
adults. Methods In a randomized, parallel-group, observer-masked, community-based …

Executive function declines with age, but engaging in aerobic exercise may attenuate
decline. One mechanism by which aerobic exercise may preserve executive function is …

Physical and cognitive exercise may prevent or delay dementia in later life but the neural
mechanisms underlying these therapeutic benefits are largely unknown. We examined …