Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

Studies on monocyte and macrophage biology and differentiation have revealed the
pleiotropic activities of these cells. Macrophages are tissue sentinels that maintain tissue …

Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells,
contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging …

Novel experimental approaches such as fate-map** and single-cell analysis have brought
fresh insight into monocyte development and function over the past decade and helped …

The mononuclear phagocyte system (MPS) has historically been categorized into
monocytes, dendritic cells and macrophages on the basis of functional and phenotypical …

Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to
peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that
expand during cancer, inflammation and infection, and that have a remarkable ability to …

Macrophages display remarkable plasticity and can change their physiology in response to
environmental cues. These changes can give rise to different populations of cells with …

Heterogeneity of the macrophage lineage has long been recognized and, in part, is a result
of the specialization of tissue macrophages in particular microenvironments. Circulating …

Monocytes participate critically in atherosclerosis. There are 2 major subsets expressing
different chemokine receptor patterns: CCR2+ CX3CR1+ Ly-6Chi and CCR2–CX3CR1++ …