Natural-product-derived cytotoxics remain a mainstay in current chemotherapy. 1 This
review focuses on the current level of understanding and emerging trends relevant to the …

The rationale for the development of prodrugs relies upon delivery of higher concentrations
of a drug to target cells compared to administration of the drug itself. In the last decades …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

DNA interstrand cross-links (ICLs) are very toxic to dividing cells, because they induce
mutations, chromosomal rearrangements and cell death. Inducers of ICLs are important …

CC-1065 and the duocarmycins are the parent members of a potent class of naturally
occurring antitumor antibiotics that exert their biological properties through the sequence …

This review focuses on the chemical and enzymatic aspects of the reductive activation of
mitomycin C, its disulfide analogs KW-2149 and BMS-181174, and, in less detail, FR66979 …

Interstrand crosslinks (ICLs) are a highly toxic form of DNA damage. ICLs can interfere with
vital biological processes requiring separation of the two DNA strands, such as replication …

The mitomycins (Figure 1) are a unique family of natural products with a rich history. Hata
and co-workers at Kwoya Hakko Kogyo Co. in Japan first isolated mitomycins A and B from …

Mitomycin C (MMC) is a chemotherapeutic drug that requires an enzymatic bioreduction to
exert its biological effects. Upon reduction, MMC is converted into a highly reactive bis …

Mitomycin C (MMC) is the prototype bioreductive DNA alkylating agent. To exploit its unique
properties and maximize patient responses, different therapeutic approaches have been …