Hypoxic radioresistance: can ROS be the key to overcome it?
Radiotherapy is a mainstay treatment for many types of cancer and kills cancer cells via
generation of reactive oxygen species (ROS). Incorporating radiation with pharmacological …
generation of reactive oxygen species (ROS). Incorporating radiation with pharmacological …
The role of p53 in determining sensitivity to radiotherapy
AV Gudkov, EA Komarova - Nature Reviews Cancer, 2003 - nature.com
Ionizing radiation (IR) has proven to be a powerful medical treatment in the fight against
cancer. Rational and effective use of its killing power depends on understanding IR …
cancer. Rational and effective use of its killing power depends on understanding IR …
Chemical radiosensitizers for use in radiotherapy
P Wardman - Clinical oncology, 2007 - Elsevier
Radiosensitizers are intended to enhance tumour cell killing while having much less effect
on normal tissues. Some drugs target different physiological characteristics of the tumour …
on normal tissues. Some drugs target different physiological characteristics of the tumour …
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
J Aragonés, M Schneider, K Van Geyte, P Fraisl… - Nature …, 2008 - nature.com
Abstract HIF prolyl hydroxylases (PHD1–3) are oxygen sensors that regulate the stability of
the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that …
the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that …
Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects
J Verrax, PB Calderon - Free Radical Biology and Medicine, 2009 - Elsevier
Recently, it has been proposed that pharmacologic concentrations of ascorbate (vitamin C)
can be reached by intravenous injection. Because high doses of ascorbate have been …
can be reached by intravenous injection. Because high doses of ascorbate have been …
Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications
This review paper attempts to provide an overview of the principles and techniques that are
often termed electron paramagnetic resonance (EPR) oximetry. The paper discusses the …
often termed electron paramagnetic resonance (EPR) oximetry. The paper discusses the …
Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy
The combination of radiotherapy and antiangiogenic strategies has been shown to increase
the tumor response in various experimental models. The rationale for this cotherapy was …
the tumor response in various experimental models. The rationale for this cotherapy was …
The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases
R Marullo, M Castro, S Yomtoubian… - Science …, 2021 - science.org
Selected patients with brain metastases (BM) are candidates for radiotherapy. A lactatogenic
metabolism, common in BM, has been associated with radioresistance. We demonstrated …
metabolism, common in BM, has been associated with radioresistance. We demonstrated …
The role of imaging biomarkers to guide pharmacological interventions targeting tumor hypoxia
B Gallez - Frontiers in pharmacology, 2022 - frontiersin.org
Hypoxia is a common feature of solid tumors that contributes to angiogenesis, invasiveness,
metastasis, altered metabolism and genomic instability. As hypoxia is a major actor in tumor …
metastasis, altered metabolism and genomic instability. As hypoxia is a major actor in tumor …
Assessing tumor oxygenation for predicting outcome in radiation oncology: a review of studies correlating tumor hypoxic status and outcome in the preclinical and …
Tumor hypoxia is recognized as a limiting factor for the efficacy of radiotherapy, because it
enhances tumor radioresistance. It is strongly suggested that assessing tumor oxygenation …
enhances tumor radioresistance. It is strongly suggested that assessing tumor oxygenation …