Given the high attrition rates, substantial costs and slow pace of new drug discovery and
development, repurposing of'old'drugs to treat both common and rare diseases is …

Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …

Infectious diseases account for nearly one fifth of the worldwide death toll every year. The
continuous increase of drug‐resistant pathogens is a big challenge for treatment of …

High-throughput drug combination screening provides a systematic strategy to discover
unexpected combinatorial synergies in pre-clinical cell models. However, phenotypic …

Antimicrobial resistance seriously threatened human health. Combination therapy is
generally an effective strategy to fight resistance, while some data on its effects are …

Drug repurposing is a more inexpensive and shorter approach than the traditional drug
discovery and development process. The concept of identifying a potent molecule from a …

Multidrug resistance (MDR) is a significant issue associated with the clinical application of
antibiotics. It is also challenging to discover and develop new antibiotics with novel …

The bacterial pathogens Streptococcus agalactiae (GBS) and Staphylococcus aureus (S.
aureus) cause serious infections in humans and animals. The emergence of antibiotic …

The substantial number of compounds that have been identified and utilized as
antimicrobials in human foods has resulted in numerous methods of evaluation of …

Highlights•Drug combinations improve efficacy and permit dose reductions of each
drug.•Lowering the dose of combined drugs prevents concentration-associated …