Functionalized nanomaterials capable of crossing the blood–brain barrier
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …
regulates exchanges between the central nervous system parenchyma and blood vessels …
[HTML][HTML] Lipid-based nanoparticles to address the limitations of GBM therapy by overcoming the blood-brain barrier, targeting glioblastoma stem cells, and …
C Zhao, X Zhu, J Tan, C Mei, X Cai, F Kong - Biomedicine & …, 2024 - Elsevier
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor,
characterized by high heterogeneity, strong invasiveness, poor prognosis, and a low …
characterized by high heterogeneity, strong invasiveness, poor prognosis, and a low …
[HTML][HTML] Lipid carriers for mRNA delivery
W Zhang, Y Jiang, Y He, H Boucetta, J Wu… - … Pharmaceutica Sinica B, 2023 - Elsevier
Messenger RNA (mRNA) is the template for protein biosynthesis and is emerging as an
essential active molecule to combat various diseases, including viral infection and cancer …
essential active molecule to combat various diseases, including viral infection and cancer …
Nanostructured lipid carriers: a promising drug carrier for targeting brain tumours
Background In recent years, the field of nanotechnology and nanomedicine has transformed
the pharmaceutical industry with the development of novel drug delivery systems that …
the pharmaceutical industry with the development of novel drug delivery systems that …
[HTML][HTML] Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs
Lipid nanoparticle (LNP)-based drug delivery systems have become the most clinically
advanced non-viral delivery technology. LNPs can encapsulate and deliver a wide variety of …
advanced non-viral delivery technology. LNPs can encapsulate and deliver a wide variety of …
[HTML][HTML] Solid lipid nanoparticles: Multitasking nano-carriers for cancer treatment
Despite all the advances seen in recent years, the severe adverse effects and low specificity
of conventional chemotherapy are still challenging problems regarding cancer treatment …
of conventional chemotherapy are still challenging problems regarding cancer treatment …
RNA interference (RNAi)-based therapeutics for treatment of rare neurologic diseases
ND Germain, WK Chung, PD Sarmiere - Molecular Aspects of Medicine, 2023 - Elsevier
Advances in genome sequencing have greatly facilitated the identification of genomic
variants underlying rare neurodevelopmental and neurodegenerative disorders …
variants underlying rare neurodevelopmental and neurodegenerative disorders …
Tailoring drug delivery systems by microfluidics for tumor therapy
Drug delivery systems (DDSs) for tumor treatment is a specialized method aimed at
transporting therapeutic substances, especially anticancer drugs, to specific target areas in …
transporting therapeutic substances, especially anticancer drugs, to specific target areas in …
Exploring curcumin-loaded lipid-based nanomedicine as efficient targeted therapy for Alzheimer's diseases
Alzheimer's disease (AD) is a neurological condition currently with 47 million people
suffering from it globally. AD might have many reasons such as genetic issues …
suffering from it globally. AD might have many reasons such as genetic issues …
Enhancing Methotrexate Delivery in the Brain by Mesoporous Silica Nanoparticles Functionalized with Cell-Penetrating Peptide using in Vivo and ex Vivo Monitoring
The blood–brain barrier (BBB) acts as a physical/biochemical barrier that protects brain
parenchyma from potential hazards exerted by different xenobiotics found in the systemic …
parenchyma from potential hazards exerted by different xenobiotics found in the systemic …