The blood–brain barrier: Structure, regulation and drug delivery

D Wu, Q Chen, X Chen, F Han, Z Chen… - Signal transduction and …, 2023 - nature.com
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Micro/nanosystems for controllable drug delivery to the brain

M Tian, Z Ma, GZ Yang - The Innovation, 2024 - cell.com
Drug delivery to the brain is crucial in the treatment for central nervous system disorders.
While significant progress has been made in recent years, there are still major challenges in …

A tool for monitoring cell type–specific focused ultrasound neuromodulation and control of chronic epilepsy

KR Murphy, JS Farrell, JL Gomez, QG Stedman… - Proceedings of the …, 2022 - pnas.org
Focused ultrasound (FUS) is a powerful tool for noninvasive modulation of deep brain
activity with promising therapeutic potential for refractory epilepsy; however, tools for …

Roadmap for clinical translation of mobile microrobotics

U Bozuyuk, P Wrede, E Yildiz, M Sitti - Advanced Materials, 2024 - Wiley Online Library
Medical microrobotics is an emerging field to revolutionize clinical applications in
diagnostics and therapeutics of various diseases. On the other hand, the mobile …

[HTML][HTML] TGF-β as a key modulator of astrocyte reactivity: disease relevance and therapeutic implications

J Luo - Biomedicines, 2022 - mdpi.com
Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …

[HTML][HTML] Translating ultrasound-mediated drug delivery technologies for CNS applications

E Perolina, S Meissner, B Raos, B Harland… - Advanced Drug Delivery …, 2024 - Elsevier
Ultrasound enhances drug delivery into the central nervous system (CNS) by opening
barriers between the blood and CNS and by triggering release of drugs from carriers. A key …

Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system

P Zhu, I Simon, I Kokalari, DS Kohane… - Advanced Drug Delivery …, 2024 - Elsevier
Ultrasound is a promising technology to address challenges in drug delivery, including
limited drug penetration across physiological barriers and ineffective targeting. Here we …

Ultrasound robotics for precision therapy

ADC Fonseca, D Ahmed - Advanced Drug Delivery Reviews, 2024 - Elsevier
In recent years, the application of microrobots in precision therapy has gained significant
attention. The small size and maneuverability of these micromachines enable them to …

Review of noninvasive or minimally invasive deep brain stimulation

X Liu, F Qiu, L Hou, X Wang - Frontiers in Behavioral Neuroscience, 2022 - frontiersin.org
Brain stimulation is a critical technique in neuroscience research and clinical application.
Traditional transcranial brain stimulation techniques, such as transcranial magnetic …

Ultrasound‐Sensitive Intelligent Nanosystems: A Promising Strategy for the Treatment of Neurological Diseases

X Pan, W Huang, G Nie, C Wang… - Advanced Materials, 2024 - Wiley Online Library
Neurological diseases are a major global health challenge, affecting hundreds of millions of
people worldwide. Ultrasound therapy plays an irreplaceable role in the treatment of …