Peroxisome proliferator activated receptor alpha (PPAR-α) belongs to the family of ligand-
regulated nuclear receptors (PPARs). These receptors after heterodimerization with retinoid …

Mood disorders and type 2 diabetes mellitus (T2DM) are prevalent conditions that often co-
occur. We reviewed the available evidence from longitudinal and Mendelian randomisation …

Obesity and mood disorders are highly prevalent and co-morbid. Epidemiological studies
have highlighted the public health relevance of this association, insofar as both conditions …

Background Cognitive dysfunction in major depressive disorder (MDD) encompasses
several domains, including but not limited to executive function, verbal memory, and …

Obesity markedly increases the odds of develo** depression. Depressed mood not only
impairs motivation, quality of life and overall functioning but also increases the risks of …

While the insulin receptor (IR) was found in the CNS decades ago, the brain was long
considered to be an insulin‐insensitive organ. This view is currently revisited, given …

Background: Mounting evidence demonstrates enhanced systemic levels of inflammatory
mediators in depression, indicating that inflammation may play a role in the etiology and …

Major depression is a common, recurrent mental illness that affects millions of people
worldwide. Recently, a unique fast neuroprotective and antidepressant treatment effect has …

Major depression is associated with a 4-fold increased risk for premature death, largely
accounted by cardiovascular disease (CVD). The relationship between depression and CVD …

Abstract Type 2 Diabetes Mellitus (T2DM) and Major Depressive Disorder (MDD) are
leading causes of disability worldwide. Indeed, both are costly and burdensome diseases at …