CD8 T cells comprising the memory pool display considerable heterogeneity, with individual
cells differing in phenotype and function. This review will focus on our current understanding …

Despite the overwhelming success of vaccines in preventing infectious diseases, there
remain numerous globally devastating diseases without fully protective vaccines, particularly …

T cells have crucial roles in protection against infection and cancer. Although the trafficking
of memory T cells around the body is integral to their capacity to provide immune protection …

Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following
a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive …

Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …

Tissues such as the skin and mucosae are frequently exposed to microbial pathogens.
Infectious agents must be quickly and efficiently controlled by our immune system, but the …

The liver has vital metabolic and clearance functions that involve the uptake of nutrients,
waste products and pathogens from the blood. In addition, its unique immunoregulatory …

Induction of antigen-specific CD8+ T cells offers the prospect of immunization against many
infectious diseases, but no subunit vaccine has induced CD8+ T cells that correlate with …

Abstract Development of a malaria vaccine remains a critical priority to decrease clinical
disease and mortality and facilitate eradication. Accordingly, RTS, S, a protein-subunit …