The mucosal lining of the gut has co-evolved with a diverse microbiota over millions of
years, leading to the development of specialized mechanisms to actively limit the invasion of …

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) represents the initial
tumor suppressor gene identified to possess phosphatase activity, governing various …

Tumor-initiating stem cells (TSCs) are critical for drug resistance and immune escape.
However, the mutual regulations between TSC and tumor microenvironment (TME) remain …

The capacity to regenerate lost tissues varies significantly among animals. Some phyla,
such as the annelids, display substantial regenerating abilities, although little is known …

Intestinal stem cells (ISCs) sustain epithelial renewal by dynamically altering behaviors of
proliferation and differentiation in response to various nutrition and stress inputs. However …

The delicate balance between the homeostatic maintenance and regenerative capacity of
the intestine makes this a fascinating tissue of study. The intestinal epithelium undergoes …

The intestinal epithelial regeneration is driven by intestinal stem cells under homeostatic
conditions. Differentiated intestinal epithelial cells, such as Paneth cells, are capable of …

Simple Summary Colorectal cancer is the third leading cause of cancer death globally. As
well as the adverse health implications for the individual, there are also considerable …

The importance of gut barrier integrity in intestinal homeostasis and the consequences of its
alteration in the etiology of human pathologies have been subjects of exponentially growing …

Background and aims Active intestinal stem cells are prone to injury by ionizing radiation.
We previously showed that upon radiation-induced injury, normally quiescent reserve …