Publisher Summary This chapter reviews papers that were published in 2008 on reactions
and syntheses of furans and benzofurans and their derivatives. Reviews published in 2008 …

Nucleic acid therapeutics such as antisense and small interfering RNA (siRNA) have
attracted increasing attention as innovative medicines that interfere with and/or modify gene …

Based on the sequence-specific recognition of target duplex DNA by triplexforming
oligonucleotides (TFOs) at the major groove side, the antigene strategy has been exploited …

Several reviews dealing with C‐nucleosides covering biological applications and synthetic
methods have been published. This chapter focuses on the chemical synthetic procedures …

Pyrazolopyrimidines are composed of a pyrazole ring fused with pyrimidine moiety, unlike
the imidazole moiety in purines; they are initially reported as adenosine receptor …

We have previously developed the innovative bicyclic nucleoside analogues (WNA) for the
formation of the triplex DNA. The WNA analogue consists of an aromatic ring and a …

(1 S, 3 S, 4 R)-1-Phenyl-1-thymidyl-3-hydroxy-4-hydroxymethylcyclopentane (10) and their
analogs were synthesized, incorporated into the oligodeoxynucleotides, and their properties …

Modified nucleoside analogues are of great biological importance as antiviral and
antitumoral agents. There is special interest in the preparation of C-aryl nucleosides with an …

N2‐Isobutyrylguanine was prepared by treatment of guanine with isobutyryl chloride. Two
tautomers, 1, 7‐dihydro‐2‐(isobutyroyl) amino‐6H‐purin‐6‐one and 1, 9‐dihydro‐2 …

The sequence-specific triplex formation against duplex DNA offers a potential basis for
genome targeting technology, such as diagnostics, regulation of gene expression and …