Over the last few decades, hot melt extrusion (HME) has emerged as a successful
technology for a broad spectrum of applications in the pharmaceutical industry. As indicated …

The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt
extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where …

Introduction: Amorphous solid dispersions are considered as one of the most powerful
strategies to formulate poorly soluble drugs. They are made up of an active pharmaceutical …

Transcutaneous immunization (TCI) has the advantages of safety, high efficiency, non-
invasiveness and convenient use. The key for a TCI system is transdermal targeted delivery …

The glass transition temperature (T g) governs the mechanical and physical performances of
polymeric materials and thus their ultimate applications. Although an extensive body of …

In this work, the feasibility of ultra-high drug loaded amorphous solid dispersions (ASDs) for
the poorly soluble itraconazole, mebendazole and celecoxib via solvent electrospinning in …

Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …

Amorphous solid dispersion (ASD) formulation development is frequently difficult owing to
the inherent physical instability of the amorphous form, and limited understanding of the …

The evolving challenges associated with the development of poorly soluble drug molecules
have been met with major advances in drug solubilization. In particular, amorphous solid …

Our main aim in the present investigation, development and evaluation of the Niclosamide
(NCL) based nanocrystals (NC) and hydrogel to provide effective anti-psoriatic activity. The …