Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?

S Deleu, K Machiels, J Raes, K Verbeke, S Vermeire - EBioMedicine, 2021 - thelancet.com
The gut microbiome and the intestinal immune system are driving contributors to
inflammatory bowel diseases (IBD). Both have an important signalling factor in common …

SCFA: mechanisms and functional importance in the gut

C Martin-Gallausiaux, L Marinelli… - Proceedings of the …, 2021 - cambridge.org
In recent years, the importance of the gut microbiota in human health has been revealed and
many publications have highlighted its role as a key component of human physiology …

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

W Yang, Y Cong - Cellular & molecular immunology, 2021 - nature.com
The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations
in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in …

Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids

CH Kim - Cellular & molecular immunology, 2021 - nature.com
A mounting body of evidence indicates that dietary fiber (DF) metabolites produced by
commensal bacteria play essential roles in balancing the immune system. DF, considered …

Regulation of immune cell function by short‐chain fatty acids

R Corrêa‐Oliveira, JL Fachi, A Vieira… - Clinical & …, 2016 - Wiley Online Library
Short‐chain fatty acids (SCFAs) are bacterial fermentation products, which are chemically
composed by a carboxylic acid moiety and a small hydrocarbon chain. Among them, acetic …

Are short chain fatty acids in gut microbiota defensive players for inflammation and atherosclerosis?

H Ohira, W Tsutsui, Y Fujioka - Journal of atherosclerosis and …, 2017 - jstage.jst.go.jp
Intestinal flora (microbiota) have recently attracted attention among lipid and carbohydrate
metabolism researchers. Microbiota metabolize resistant starches and dietary fibers through …

Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids

A Cait, MR Hughes, F Antignano, J Cait… - Mucosal …, 2018 - nature.com
The mammalian gastrointestinal tract harbors a microbial community with metabolic activity
critical for host health, including metabolites that can modulate effector functions of immune …

[PDF][PDF] Gut microbiota-derived short-chain fatty acids, T cells, and inflammation

CH Kim, J Park, M Kim - Immune network, 2014 - synapse.koreamed.org
T cells are central players in the regulation of adaptive immunity and immune tolerance. In
the periphery, T cell differentiation for maturation and effector function is regulated by a …

Microbiome-modulated metabolites at the interface of host immunity

E Blacher, M Levy, E Tatirovsky… - The Journal of …, 2017 - journals.aai.org
The mammalian gastrointestinal tract and associated mucosal immune system harbor a
large repertoire of metabolites of prokaryotic and eukaryotic origin that play important roles …

Commensal bacteria at the interface of host metabolism and the immune system

JR Brestoff, D Artis - Nature immunology, 2013 - nature.com
The mammalian gastrointestinal tract, the site of digestion and nutrient absorption, harbors
trillions of beneficial commensal microbes from all three domains of life. Commensal …