The past decade has witnessed remarkable advances in the simultaneous measurement of
neuronal activity across many brain regions, enabling fundamentally new explorations of the …

Advances in fluorescence microscopy enable monitoring larger brain areas in-vivo with finer
time resolution. The resulting data rates require reproducible analysis pipelines that are …

Widefield microscopy can provide optical access to multi-millimeter fields of view and
thousands of neurons in mammalian brains at video rate. However, tissue scattering and …

Miniature microscopes have gained considerable traction for in vivo calcium imaging in
freely behaving animals. However, extracting calcium signals from raw videos is a …

Optical microscopy methods such as calcium and voltage imaging enable fast activity
readout of large neuronal populations using light. However, the lack of corresponding …

Over the past decade, novel optical imaging tools have been developed for imaging
neuronal activities along with the evolution of fluorescence indicators with brighter …

Chronic pain is a tremendous burden for afflicted individuals and society. Although opioids
effectively relieve pain, significant adverse outcomes limit their utility and efficacy. To …

Neuroscience and artificial intelligence (AI) share a long history of collaboration. Advances
in neuroscience, alongside huge leaps in computer processing power over the last few …

Studies over the past two decades have demonstrated that astrocytes are tightly associated
with neurons and play pivotal roles in neural circuit development, operation, and adaptation …

State-of-the-art Ca2+ imaging studies that monitor large-scale neural dynamics can produce
video datasets~ 10 terabytes or more in total size, roughly comparable to~ 10,000 …