Modeling large-volume subcutaneous injection of monoclonal antibodies with anisotropic porohyperelastic models and data-driven tissue layer geometries
Subcutaneous injection of therapeutic monoclonal antibodies (mAbs) has become one of
the fastest-growing fields in the pharmaceutical industry. The transport and mechanical …
the fastest-growing fields in the pharmaceutical industry. The transport and mechanical …
Computational modeling of the effect of skin pinch and stretch on subcutaneous injection of monoclonal antibodies using autoinjector devices
Subcutaneous injection of monoclonal antibodies (mAbs) has experienced unprecedented
growth in the pharmaceutical industry due to its benefits in patient compliance and cost …
growth in the pharmaceutical industry due to its benefits in patient compliance and cost …
Transport and distribution of biotherapeutics in different tissue layers after subcutaneous injection
The subcutaneous injection is the main route of administration for monoclonal antibodies
(mAbs) and several other biotherapeutics due to the patient comfort and cost-effectiveness …
(mAbs) and several other biotherapeutics due to the patient comfort and cost-effectiveness …
Modeling drug transport and absorption in subcutaneous injection of monoclonal antibodies: Impact of tissue deformation, devices, and physiology
The pharmaceutical industry has experienced a remarkable increase in the use of
subcutaneous injection of monoclonal antibodies (mAbs), attributed mainly to its advantages …
subcutaneous injection of monoclonal antibodies (mAbs), attributed mainly to its advantages …
Stabilized isogeometric formulation of the multi-network poroelasticity and transport model (mpet2) for subcutaneous injection of monoclonal antibodies
The MPET 2 model couples the multi-network poroelastic theory (MPET) with solute
transport equations and provides predictions of the material deformation, fluid dynamics …
transport equations and provides predictions of the material deformation, fluid dynamics …
Optimizing autoinjector devices using physics-based simulations and Gaussian processes
Autoinjectors are becoming a primary drug delivery option to the subcutaneous space.
These devices need to work robustly and autonomously to maximize drug bio-availability …
These devices need to work robustly and autonomously to maximize drug bio-availability …
A quadriphasic mechanical model of the human dermis
D Sachs, R Jakob, G Restivo, J Hafner… - … and Modeling in …, 2024 - Springer
The present study investigates the multiphasic nature of the mechanical behavior of human
dermis. Motivated by experimental observations and by consideration of its composition, a …
dermis. Motivated by experimental observations and by consideration of its composition, a …
MPET2: a multi-network poroelastic and transport theory for predicting absorption of monoclonal antibodies delivered by subcutaneous injection
Subcutaneous injection of monoclonal antibodies (mAbs) has attracted much attention in the
pharmaceutical industry. During the injection, the drug is delivered into the tissue producing …
pharmaceutical industry. During the injection, the drug is delivered into the tissue producing …
Mixed-dimensional multi-scale poroelastic modeling of adipose tissue for subcutaneous injection
Subcutaneous injection of therapeutic monoclonal antibodies (mAbs) has gained increasing
interest in the pharmaceutical industry. The transport, distribution and absorption of mAbs in …
interest in the pharmaceutical industry. The transport, distribution and absorption of mAbs in …
The role of initial lymphatics in the absorption of monoclonal antibodies after subcutaneous injection
The subcutaneous injection is the most common method of administration of monoclonal
antibodies (mAbs) due to the patient's comfort and cost-effectiveness. However, the …
antibodies (mAbs) due to the patient's comfort and cost-effectiveness. However, the …