Site-predictable and chemoselective C–H bond functionalization reactions offer synthetically
powerful strategies for the step-economic diversification of both feedstock and fine …

The principles of green chemistry (GC) can be comprehensively implemented in green
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …

Catalytic C (sp3)–H functionalization has provided enormous opportunities to construct
organic molecules, facilitating the derivatization of complex pharmaceutical compounds …

C–H deuteration has been intricately developed to satisfy the urgent need for site-selectively
deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope …

Key similarities and differences of Pd and Ni in catalytic systems are discussed. Overall, Ni
and Pd catalyze a vast number of similar C–C and C–heteroatom bond-forming reactions …

Over the past few decades, the advent of C–H activation has led to a rethink among
chemists about the synthetic strategies employed for multi-step transformations. Indeed …

Dipolar aprotic and ethereal solvents comprise just over 40% of all organic solvents utilized
in synthetic organic, medicinal, and process chemistry. Unfortunately, many of the common …

Transition metal–catalyzed C─ H bond activation and borylation is a powerful synthetic
method that offers versatile synthetic transformation from organoboron compounds to …

Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …

The progress of drug discovery and development is paced by milestones reached in organic
synthesis. In the last decade, the advent of late-stage functionalization (LSF) reactions has …