Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

Nanomaterials | Free Full-Text | A Review of the Current State of Magnetic Force Microscopy to
Unravel the Magnetic Properties of Nanomaterials Applied in Biological Systems and Future …

Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and
correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC …

Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or
unnecessary cells in multicellular organisms. Various types of intracellular stress trigger …

Lung cancer ranks among the most prevalent forms of cancer and remains a significant
factor in cancer-related mortality across the world. It poses significant challenges to …

Background High-grade serous ovarian carcinoma is characterised by TP53 mutations, DNA
repair defects, and genomic instability. We hypothesised that prexasertib (LY2606368), a …

Ovarian cancer is the leading cause of gynecological cancer death. Improved understanding
of the biologic pathways and introduction of poly (ADP-ribose) polymerase inhibitors …

To maintain genome stability, cells have evolved various DNA repair pathways to deal with
oxidative DNA damage. DNA damage response (DDR) pathways, including ATM-Chk2 and …

Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment.
However, they have debilitating side effects in normal tissues and induce ototoxicity …

ATRX, a chromatin remodeler protein, is recurrently mutated in H3F3A-mutant pediatric
glioblastoma (GBM) and isocitrate dehydrogenase (IDH)-mutant grade 2/3 adult glioma …