Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …

The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Glutamate is the primary excitatory neurotransmitter in mammalian brain. Disturbances in
glutamate-mediated neurotransmission have been increasingly documented in a range of …

Antipsychotic drugs are the mainstay in the treatment of schizophrenia. However, one-third
of patients do not show adequate improvement in positive symptoms with non-clozapine …

Studies of brain network connectivity improved understanding on brain changes and
adaptation in response to different pathologies. Synaptic plasticity, the ability of neurons to …

Nitric oxide (NO) is a multifunctional signalling molecule and a neurotransmitter that plays
an important role in physiological and pathophysiological processes. In physiological …

The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …

The observation that antagonists of the N-methyl-D-aspartate receptor (NMDAR), such as
phencyclidine (PCP) and ketamine, transiently induce symptoms of acute schizophrenia had …