Osteoarthritis (OA) refers to a group of mechanically-induced joint disorders to which both
genetic and acquired factors contribute. Current pathophysiological concepts focus on OA …

BACKGROUND: Osteoarthritis (OA) is a multifactorial disease with strong genetic and
occupational components. Although published studies have described several risk factors …

Osteoarthritis is a common complex disease imposing a large public-health burden. Here,
we performed a genome-wide association study for osteoarthritis, using data across 16.5 …

Adult height is a model polygenic trait, but there has been limited success in identifying the
genes underlying its normal variation. To identify genetic variants influencing adult human …

Knee osteoarthritis remains a tremendous public health concern, both in terms of health‐
related quality of life and financial burden of disease. Translational research is a critical step …

Identifying genetic variants that influence human height will advance our understanding of
skeletal growth and development. Several rare genetic variants have been convincingly and …

The origin, roles and fate of progenitor cells forming synovial joints during limb
skeletogenesis remain largely unclear. Here we produced prenatal and postnatal genetic …

Height is correlated with risk to certain diseases and various socio-economic outcomes. As
an easy to observe and measure trait, it has been a classic paradigm in the emergence of …

Articular cartilage is formed at the end of epiphyses in the synovial joint cavity and
permanently contributes to the smooth movement of synovial joints. Most skeletal elements …

Osteoarthritis (OA) is the most prevalent form of arthritis in the elderly. A large body of
evidence, including familial aggregation and classic twin studies, indicates that primary OA …