Cancer stem cells: advances in knowledge and implications for cancer therapy

X Chu, W Tian, J Ning, G **ao, Y Zhou… - … and Targeted Therapy, 2024 - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Harnessing the potential of hydrogels for advanced therapeutic applications: Current achievements and future directions

P Lu, D Ruan, M Huang, M Tian, K Zhu… - Signal transduction and …, 2024 - nature.com
The applications of hydrogels have expanded significantly due to their versatile, highly
tunable properties and breakthroughs in biomaterial technologies. In this review, we cover …

Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

AL Correia, JC Guimaraes, P Auf der Maur, D De Silva… - Nature, 2021 - nature.com
The persistence of undetectable disseminated tumour cells (DTCs) after primary tumour
resection poses a major challenge to effective cancer treatment,–. These enduring dormant …

[HTML][HTML] Functionalized liposomes for targeted breast cancer drug delivery

J Nel, K Elkhoury, É Velot, A Bianchi, S Acherar… - Bioactive materials, 2023 - Elsevier
Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and
treatment strategies, it remains a prominent cause of female mortality worldwide …

The spatiotemporal program of zonal liver regeneration following acute injury

S Ben-Moshe, T Veg, R Manco, S Dan, D Papinutti… - Cell Stem Cell, 2022 - cell.com
The liver carries a remarkable ability to regenerate rapidly after acute zonal damage. Single-
cell approaches are necessary to study this process, given the spatial heterogeneity of liver …

The chemokine receptor CXCR4 in cell proliferation and tissue regeneration

ME Bianchi, R Mezzapelle - Frontiers in Immunology, 2020 - frontiersin.org
The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that
orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone …

The role of tumor microenvironment in multiple myeloma development and progression

A Garcia-Ortiz, Y Rodríguez-García, J Encinas… - Cancers, 2021 - mdpi.com
Simple Summary Multiple Myeloma (MM) is a hematologic malignancy caused by aberrant
plasma cell proliferation in the bone marrow (BM) and constitutes the second most common …

The unique structural and functional features of CXCL12

R Janssens, S Struyf, P Proost - Cellular & molecular immunology, 2018 - nature.com
The CXC chemokine CXCL12 is an important factor in physiological and pathological
processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation …

Monocyte-neutrophil entanglement in glioblastoma

D Friedmann-Morvinski… - The Journal of clinical …, 2023 - Am Soc Clin Investig
Glioblastoma (GBM) is the most belligerent and frequent brain tumor in adults. Research
over the past two decades has provided increased knowledge of the genomic and molecular …

The intricate role of CXCR4 in cancer

S Chatterjee, BB Azad, S Nimmagadda - Advances in cancer research, 2014 - Elsevier
Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …