Ionizing radiation has become the most effective way to modify natural and synthetic
polymers through crosslinking, degradation, and graft polymerization. This review will …

Human societies have, in all ages, modified the original form of metals and metalloids in
their living environment for their survival and technical development. In many cases, these …

The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of
excitatory synaptic transmission in the central nervous system. Here we have determined …

A molecular description of oxygen and peroxide activation in biological systems is difficult,
because electrons liberated during X-ray data collection reduce the active centres of redox …

G-protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that
modulate biological function by initiating cellular signalling in response to chemically …

Cholinesterases are among the most efficient enzymes known. They are divided into two
groups: acetylcholinesterase, involved in the hydrolysis of the neurotransmitter …

Maximum-likelihood X-ray macromolecular structure refinement in BUSTER has been
extended with restraints facilitating the exploitation of structural similarity. The similarity can …

Abstract Neurotensin (NTS) is a 13-amino-acid peptide that functions as both a
neurotransmitter and a hormone through the activation of the neurotensin receptor NTSR1, a …

Transient receptor potential (TRP) melastatin 4 (TRPM4) is a widely expressed cation
channel associated with a variety of cardiovascular disorders. TRPM4 is activated by …

The remarkable diversity, glycosylation and conformational flexibility of the human
immunodeficiency virus type 1 (HIV-1) envelope (Env), including substantial rearrangement …