Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is the most widely
used herbicide in the world. It can persist in the environment for days or months, and its …

Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

Ischemic stroke is the leading cause of human disability and mortality in the world. The main
problem in stroke therapy is the search of efficient neuroprotector capable to rescue neurons …

Puerarin is an isoflavone compound derived from Pueraria lobata in traditional Chinese
medicine. Accumulating evidence has indicated that puerarin demonstrates multiple …

Acute ischemic stroke (AIS) afflicts millions of individuals worldwide. Despite the
advancements in thrombolysis and thrombectomy facilitating proximal large artery …

The Ca 2+/Calmodulin (CaM)-dependent protein kinase II (CaMKII) is activated by Ca
2+/CaM, but becomes partially autonomous (Ca 2+-independent) upon autophosphorylation …

Neuronal activity induces intracellular Ca2+ increase, which triggers activation of a series of
Ca2+‐dependent signaling cascades. Among these, the multifunctional Ca2+/calmodulin …

Oligomeric forms of amyloid-forming proteins are believed to be the principal initiating
bioactive species in many neurodegenerative disorders, including Alzheimer's disease (AD) …

Due to global population aging and modern lifestyle changes, the incidence of central
nervous system (CNS) disorders, such as neurodegenerative diseases, neuropsychiatric …

Ischemia is a common pathological condition present in many neurodegenerative diseases,
including ischemic stroke, retinal vascular occlusion, diabetic retinopathy, and glaucoma …