Studying how genetic predispositions come together with environmental factors to contribute
to complex behavioral outcomes has great potential for advancing the understanding of the …

It has been more than a decade since the first chromosome conformation capture (3C) assay
was described. The assay was originally devised to measure the frequency with which two …

Histone H3 lysine 4 mono-methylation (H3K4me1) marks poised or active enhancers.
KMT2C (MLL3) and KMT2D (MLL4) catalyze H3K4me1, but their histone methyltransferase …

Abstract WashU Epigenome Browser (https://epigenomegateway. wustl. edu/browser/) is a
web-based genomic data exploration tool that provides visualization, integration, and …

We present HiGlass, an open source visualization tool built on web technologies that
provides a rich interface for rapid, multiplex, and multiscale navigation of 2D genomic maps …

Hi-C experiments study how genomes fold in 3D, generating contact maps containing
features as small as 20 bp and as large as 200 Mb. Here we introduce Juicebox, a tool for …

Oncogenes are activated through well-known chromosomal alterations such as gene fusion,
translocation, and focal amplification. In light of recent evidence that the control of key genes …

Abstract The Ensembl project (http://www. ensembl. org) is a system for genome annotation,
analysis, storage and dissemination designed to facilitate the access of genomic annotation …

Here, we introduce the 3D Genome Browser, http://3dgenome. org, which allows users to
conveniently explore both their own and over 300 publicly available chromatin interaction …

High-order chromatin structure plays important roles in gene expression regulation.
Knowledge of the dynamics of 3D chromatin structures during mammalian embryo …