Principal component analysis: A natural approach to data exploration
Principal component analysis (PCA) is often applied for analyzing data in the most diverse
areas. This work reports, in an accessible and integrated manner, several theoretical and …
areas. This work reports, in an accessible and integrated manner, several theoretical and …
Cloud computing for genomic data analysis and collaboration
Next-generation sequencing has made major strides in the past decade. Studies based on
large sequencing data sets are growing in number, and public archives for raw sequencing …
large sequencing data sets are growing in number, and public archives for raw sequencing …
Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)
Key questions in COVID-19 are the duration and determinants of infectious virus shedding.
Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 …
Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 …
[HTML][HTML] The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma
Biological heterogeneity in diffuse large B cell lymphoma (DLBCL) is partly driven by cell-of-
origin subtypes and associated genomic lesions, but also by diverse cell types and cell …
origin subtypes and associated genomic lesions, but also by diverse cell types and cell …
Sublethal necroptosis signaling promotes inflammation and liver cancer
It is currently not well known how necroptosis and necroptosis responses manifest in vivo.
Here, we uncovered a molecular switch facilitating reprogramming between two alternative …
Here, we uncovered a molecular switch facilitating reprogramming between two alternative …
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins
by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific …
by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific …
Defining the KRAS-and ERK-dependent transcriptome in KRAS-mutant cancers
How the KRAS oncogene drives cancer growth remains poorly understood. Therefore, we
established a systemwide portrait of KRAS-and extracellular signal–regulated kinase (ERK) …
established a systemwide portrait of KRAS-and extracellular signal–regulated kinase (ERK) …
Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment
We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …
xCell: digitally portraying the tissue cellular heterogeneity landscape
Tissues are complex milieus consisting of numerous cell types. Several recent methods
have attempted to enumerate cell subsets from transcriptomes. However, the available …
have attempted to enumerate cell subsets from transcriptomes. However, the available …
Intertumoral heterogeneity within medulloblastoma subgroups
While molecular subgrou** has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …