Recently, the term monoclonal gammopathy of renal significance (MGRS) was introduced to
distinguish monoclonal gammopathies that result in the development of kidney disease from …

Exosomes are released by most cells and can be isolated from all biofluids including urine.
Exosomes are small vesicles formed as part of the endosomal pathway that contain cellular …

We propose a straightforward method to estimate the purity of vesicle preparations by
comparing the ratio of nano-vesicle counts to protein concentration, using tools such as the …

AL amyloidosis (light chain; previously also called primary amyloidosis) is a systemic
disease characterized by an amyloid deposition process affecting many organs, and which …

Increasing attention has been given to secreted extracellular vesicles (EVs) in the past
decades, especially in the portrayal of their molecular cargo and role as messengers in both …

Kidney injury is a common complication of multiple myeloma and other plasma cell
dyscrasias, and it is associated with increased mortality. Multiple pathogenic mechanisms …

Light chain (AL) amyloidosis is a devastating, complex, and incurable protein misfolding
disease. It is characterized by an abnormal proliferation of plasma cells (fully differentiated B …

Recent years have witnessed a rapid growth in our understanding of the pathogenic
property of monoclonal proteins. It is evident that some of these small monoclonal proteins …

Extracellular vesicles (EVs) are released from almost all cells and tissues. They are able to
transport substances (eg proteins, RNA or DNA) at higher concentrations than in their …

Diabetes represents a major threat to public health and the number of patients is increasing
alarmingly in the global scale. Particularly, the diabetic kidney disease (nephropathy, DN) …