Porcine reproductive and respiratory syndrome virus (PRRSV): pathogenesis and interaction with the immune system

JK Lunney, Y Fang, A Ladinig, N Chen… - Annual review of …, 2016 - annualreviews.org
This review addresses important issues of porcine reproductive and respiratory syndrome
virus (PRRSV) infection, immunity, pathogenesis, and control. Worldwide, PRRS is the most …

Viral quasispecies evolution

E Domingo, J Sheldon, C Perales - Microbiology and Molecular …, 2012 - Am Soc Microbiol
Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV …

C Burkard, SG Lillico, E Reid, B Jackson… - PLoS …, 2017 - journals.plos.org
Porcine Reproductive and Respiratory Syndrome (PRRS) is a panzootic infectious disease
of pigs, causing major economic losses to the world-wide pig industry. PRRS manifests …

[HTML][HTML] PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity

MA Kappes, KS Faaberg - Virology, 2015 - Elsevier
Porcine reproductive and respiratory disease virus (PRRSV) has the intrinsic ability to adapt
and evolve. After 25 years of study, this persistent pathogen has continued to frustrate efforts …

Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark

K Tian, X Yu, T Zhao, Y Feng, Z Cao, C Wang, Y Hu… - PloS one, 2007 - journals.plos.org
Porcine reproductive and respiratory syndrome (PRRS) is a severe viral disease in pigs,
causing great economic losses worldwide each year. The causative agent of the disease …

The prevalent status and genetic diversity of porcine reproductive and respiratory syndrome virus in China: a molecular epidemiological perspective

Z Guo, X Chen, R Li, S Qiao, G Zhang - Virology journal, 2018 - Springer
Porcine reproductive and respiratory syndrome virus (PRRSV) has been epidemic more
than 30 years in America and 20 years in China. It is still one of the most important causative …

Improved vaccine against PRRSV: current progress and future perspective

Y Nan, C Wu, G Gu, W Sun, YJ Zhang… - Frontiers in …, 2017 - frontiersin.org
Porcine reproductive and respiratory syndrome virus (PRRSV), one of the most
economically significant pathogens worldwide, has caused numerous outbreaks during the …

Arterivirus molecular biology and pathogenesis

EJ Snijder, M Kikkert, Y Fang - Journal of General …, 2013 - microbiologyresearch.org
Arteriviruses are positive-stranded RNA viruses that infect mammals. They can cause
persistent or asymptomatic infections, but also acute disease associated with a respiratory …

Phylogeny-based evolutionary, demographical, and geographical dissection of North American type 2 porcine reproductive and respiratory syndrome viruses

M Shi, TTY Lam, CC Hon, MP Murtaugh… - Journal of …, 2010 - Am Soc Microbiol
ABSTRACT Type 2 (or North American-like) porcine reproductive and respiratory syndrome
virus (PRRSV) was first recorded in 1987 in the United States and now occurs in most …

The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins

Y Fang, EJ Snijder - Virus research, 2010 - Elsevier
Our knowledge about the structure and function of the nonstructural proteins (nsps) encoded
by the arterivirus replicase gene has advanced in recent years. The continued …