Abstract CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-
associated protein 9) is a potent technology for gene-editing. Owing to its high specificity …

Chitosan is a biotechnological derivative of chitin receiving a widespread pharmaceutical
and biomedical applications. It can be used to encapsulate and deliver cancer therapeutics …

The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being
evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the …

Aptamers are synthetic single-stranded DNA or RNA sequences selected from combinatorial
oligonucleotide libraries through the well-known in vitro selection and iteration process …

G-quadruplexes constitute a unique class of nucleic acid structures formed by G-rich
oligonucleotides of DNA-or RNA-type. Depending on their chemical nature, loops length …

Carriers of genetic material are divided into vectors of viral and non-viral origin. Viral carriers
are already successfully used in experimental gene therapies, but despite advantages such …

Abstract G-quadruplex (G4) is a non-canonical structure that is formed in G-rich sequences
of nucleic acids. G4s play important roles in vivo, such as telomere maintenance …

Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …

Nanobioconjugates are nanoscale drug delivery vehicles that have been conjugated to or
decorated with biologically active targeting ligands. These targeting ligands can be …

Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules consisting of
two ligands joined by a linker, enabling them to simultaneously bind with an E3 ligase and a …