Methods for profiling genes at the single-cell level have revolutionized our ability to study
several biological processes and systems including development, differentiation, response …

Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …

Since the advent of single-cell RNA sequencing (scRNA-seq) methodology, single-cell
analysis has become a powerful tool for exploration of cellular networks and dysregulated …

Motivation Single-cell RNA-sequencing (scRNA-seq) technologies provide an opportunity to
infer cell-specific gene regulatory networks (GRNs), which is an important challenge in …

A primary challenge in single-cell RNA sequencing (scRNA-seq) studies comes from the
massive amount of data and the excess noise level. To address this challenge, we introduce …

Inferring gene regulatory networks (GRNs) is a fundamental challenge in biology that aims
to unravel the complex relationships between genes and their regulators. Deciphering these …

Pathway analysis has been widely used to detect pathways and functions associated with
complex disease phenotypes. The proliferation of this approach is due to better …

Motivation Single-cell RNA sequencing (scRNA-seq) data provides unprecedented
opportunities to reconstruct gene regulatory networks (GRNs) at fine-grained resolution …

Extracting dynamical information from single‐cell transcriptomics is a novel task with the
promise to advance our understanding of cell state transition and interactions between …

Autoimmunity refers to the phenomenon that the body's immune system produces antibodies
or sensitized lymphocytes to its own tissues to cause an immune response. Immune …