Assumptions underlying hepatic clearance models: recognizing the influence of saturable protein...

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How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data

JA Schulz Pauly, JC Kalvass - Xenobiotica, 2024 - Taylor & Francis
Isolated perfused rat liver (IPRL) experiments have been used to answer clearance-related
questions, including evaluating the impact of pathological and physiological processes on …
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Predicting Clearance with Simple and Permeability-Limited Physiologically Based Pharmacokinetic Frameworks: Comparison of Well-Stirred, Dispersion, and Parallel …

S Nagar, R Parise, K Korzekwa - Drug Metabolism and Disposition, 2024 - Elsevier
ABSTRACT One-compartment (1C) and permeability-limited models were used to evaluate
the ability of microsomal and hepatocyte intrinsic clearances to predict hepatic clearance …
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