Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Organoids serve as a novel tool for disease modeling in three-dimensional multicellular
contexts. Static organoids, however, lack the requisite biophysical microenvironment such …

There is growing appreciation of the role that the extracellular environment plays in
regulating cell behavior. Mechanical, structural, and compositional cues, either alone or in …

Fibrinogen and fibrin are essential for hemostasis and are major factors in thrombosis,
wound healing, and several other biological functions and pathological conditions. The X …

Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

The ability of cells to sense external mechanical cues is essential for their adaptation to the
surrounding microenvironment. However, how nanoparticle mechanical properties affect cell …

From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple
scales and cell types. The convergence of bioengineering, materials science, and stem cell …

Blood clot contraction plays an important role in prevention of bleeding and in thrombotic
disorders. Here, we unveil and quantify the structural mechanisms of clot contraction at the …

Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …