Morphogenetic events during development shape the body plan and establish structural
foundations for tissue forms and functions. Acquiring spatiotemporal information of …

During organismal development, organs and systems are built following a genetic blueprint
that produces structures capable of performing specific physiological functions. Interestingly …

The role of mechanical forces driving kidney epithelial fluid transport and morphogenesis in
kidney diseases is unclear. Here, using a microfluidic platform to recapitulate fluid transport …

Formation of fluid-filled lumina by epithelial tissues is essential for organ development. How
cells control the hydraulic and cortical forces to control lumen morphology is not well …

Epithelial tissues sheath organs and electro-mechanically regulate ion and water transport
to regulate development, homeostasis, and hydrostatic organ pressure. Here, we …

Upon implantation, mammalian embryos undergo major morphogenesis and key
developmental processes such as body axis specification and gastrulation. However, limited …

Mechanics is known to play a fundamental role in many cellular and developmental
processes. Beyond active forces and material properties, osmotic pressure is believed to …

Hydraulic fracturing plays a major role in cavity formation during embryonic development,
when pressurized fluid opens microlumens at cell-cell contacts, which evolve to form a …

Post-implantation, the pluripotent epiblast in a human embryo forms a central lumen, paving
the way for gastrulation. Osmotic pressure gradients are considered the drivers of lumen …

Muscle morphogenesis is a multi-step program, starting with myoblast fusion, followed by
myotube-tendon attachment and sarcomere assembly, with subsequent sarcomere …