Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …

Wingless ligands, a family of secreted proteins, are critically involved in organ development
and tissue homeostasis by ensuring balanced rates of stem cell proliferation, cell death and …

Trophoblast migration and invasion through the decidua and maternal uterine spiral arteries
are crucial events in placentation. During this process, invasive trophoblast replace vascular …

BACKGROUND During pregnancy, maternal uterine spiral arteries (SAs) are remodelled
from minimal-flow, high-resistance vessels into larger diameter vessels with low resistance …

Invasion of placental trophoblasts into uterine tissue and vessels is an essential process of
human pregnancy and fetal development. Due to their remarkable plasticity invasive …

Embryonic stem cells (ESCs) are derived from mammalian embryos during the transition
from totipotency, when individual blastomeres can make all lineages, to pluripotency, when …

Interleukin-8 (IL8/CXCL8) is present in decidua and trophoblast, which also expresses the
IL8 receptors, CXCR1 and CXCR2. IL8 was shown to stimulate trophoblast migration. Matrix …

Leukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation.
Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes …

Trophoblast cells display a very unique capability: they physiologically invade into the
surrounding tissue. This capability is widely associated with tumours, and, indeed, the …

BACKGROUND Heparan sulphates play key roles in conception and early pregnancy
events. The role of heparin, a structural analogue, and its application to assisted conception …