Protein arginine methyltransferases and cancer
There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian
genomes, the protein products of which catalyse three types of arginine methylation …
genomes, the protein products of which catalyse three types of arginine methylation …
Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer
H Kędzierska, A Piekiełko-Witkowska - Cancer letters, 2017 - Elsevier
SR and hnRNP proteins were initially discovered as regulators of alternative splicing: the
process of controlled removal of introns and selective joining of exons through which …
process of controlled removal of introns and selective joining of exons through which …
Targeting epigenetics for cancer therapy
JW Park, JW Han - Archives of pharmacal research, 2019 - Springer
Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth
and reproduction, with main characteristics such as uncontrolled division, invading other …
and reproduction, with main characteristics such as uncontrolled division, invading other …
SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer
Objective To investigate the molecular function of splicing factor SRSF6 in colorectal cancer
(CRC) progression and discover candidate chemicals for cancer therapy through targeting …
(CRC) progression and discover candidate chemicals for cancer therapy through targeting …
Regulation of histone arginine methylation/demethylation by methylase and demethylase
J Zhang, L **g, M Li, L He… - Molecular medicine …, 2019 - spandidos-publications.com
Histone arginine methylation is a universal post-translational modification that has been
implicated in multiple cellular and sub-cellular processes, including pre-mRNA splicing …
implicated in multiple cellular and sub-cellular processes, including pre-mRNA splicing …
Protein arginine methylation/demethylation and cancer
C Poulard, L Corbo, M Le Romancer - Oncotarget, 2016 - pmc.ncbi.nlm.nih.gov
Protein arginine methylation is a common post-translational modification involved in
numerous cellular processes including transcription, DNA repair, mRNA splicing and signal …
numerous cellular processes including transcription, DNA repair, mRNA splicing and signal …
Protein arginine methyltransferase 1, a major regulator of biological processes
SRN Sudhakar, SN Khan, A Clark… - … and Cell Biology, 2023 - cdnsciencepub.com
Protein arginine methyltransferase 1 (PRMT1) is a major type I arginine methyltransferase
that catalyzes the formation of monomethyl and asymmetric dimethylarginine in protein …
that catalyzes the formation of monomethyl and asymmetric dimethylarginine in protein …
PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia
The presence of FMS-like receptor tyrosine kinase-3 internal tandem duplication (FLT3-ITD)
mutations in patients with acute myeloid leukemia (AML) is associated with poor clinical …
mutations in patients with acute myeloid leukemia (AML) is associated with poor clinical …
[HTML][HTML] Protein arginine methyltransferases as therapeutic targets in hematological malignancies
C Sauter, J Simonet, F Guidez, B Dumétier, B Pernon… - Cancers, 2022 - mdpi.com
Simple Summary This review summarizes the current findings about the cellular roles of
protein arginine methyltransferases (PRMTs) in the formation of blood cells from stem cell …
protein arginine methyltransferases (PRMTs) in the formation of blood cells from stem cell …
High expression of CPT1A predicts adverse outcomes: a potential therapeutic target for acute myeloid leukemia
Carnitine palmitoyl transferase 1A (CPT1A) protein catalyzes the rate-limiting step of Fatty-
acid oxidation (FAO) pathway, which can promote cell proliferation and suppress apoptosis …
acid oxidation (FAO) pathway, which can promote cell proliferation and suppress apoptosis …