Protein arginine methyltransferases and cancer

Y Yang, MT Bedford - Nature Reviews Cancer, 2013 - nature.com
There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian
genomes, the protein products of which catalyse three types of arginine methylation …

Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer

H Kędzierska, A Piekiełko-Witkowska - Cancer letters, 2017 - Elsevier
SR and hnRNP proteins were initially discovered as regulators of alternative splicing: the
process of controlled removal of introns and selective joining of exons through which …

Targeting epigenetics for cancer therapy

JW Park, JW Han - Archives of pharmacal research, 2019 - Springer
Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth
and reproduction, with main characteristics such as uncontrolled division, invading other …

SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer

L Wan, W Yu, E Shen, W Sun, Y Liu, J Kong, Y Wu… - Gut, 2019 - gut.bmj.com
Objective To investigate the molecular function of splicing factor SRSF6 in colorectal cancer
(CRC) progression and discover candidate chemicals for cancer therapy through targeting …

Regulation of histone arginine methylation/demethylation by methylase and demethylase

J Zhang, L **g, M Li, L He… - Molecular medicine …, 2019 - spandidos-publications.com
Histone arginine methylation is a universal post-translational modification that has been
implicated in multiple cellular and sub-cellular processes, including pre-mRNA splicing …

Protein arginine methylation/demethylation and cancer

C Poulard, L Corbo, M Le Romancer - Oncotarget, 2016 - pmc.ncbi.nlm.nih.gov
Protein arginine methylation is a common post-translational modification involved in
numerous cellular processes including transcription, DNA repair, mRNA splicing and signal …

Protein arginine methyltransferase 1, a major regulator of biological processes

SRN Sudhakar, SN Khan, A Clark… - … and Cell Biology, 2023 - cdnsciencepub.com
Protein arginine methyltransferase 1 (PRMT1) is a major type I arginine methyltransferase
that catalyzes the formation of monomethyl and asymmetric dimethylarginine in protein …

PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia

X He, Y Zhu, YC Lin, M Li, J Du, H Dong… - Blood, The Journal …, 2019 - ashpublications.org
The presence of FMS-like receptor tyrosine kinase-3 internal tandem duplication (FLT3-ITD)
mutations in patients with acute myeloid leukemia (AML) is associated with poor clinical …

[HTML][HTML] Protein arginine methyltransferases as therapeutic targets in hematological malignancies

C Sauter, J Simonet, F Guidez, B Dumétier, B Pernon… - Cancers, 2022 - mdpi.com
Simple Summary This review summarizes the current findings about the cellular roles of
protein arginine methyltransferases (PRMTs) in the formation of blood cells from stem cell …

High expression of CPT1A predicts adverse outcomes: a potential therapeutic target for acute myeloid leukemia

J Shi, H Fu, Z Jia, K He, L Fu, W Wang - EBioMedicine, 2016 - thelancet.com
Carnitine palmitoyl transferase 1A (CPT1A) protein catalyzes the rate-limiting step of Fatty-
acid oxidation (FAO) pathway, which can promote cell proliferation and suppress apoptosis …