Molecular pathogenesis of ADPKD: The polycystin complex gets complex. Autosomal-
dominant polycystic kidney disease (ADPKD) is one of the most common human monogenic …

Biologists have long known that humans experience their environment through cilia. Light,
odorant, and sound perception depend on these microtubule-filled, complex organelles …

Nephrin and NEPH1, the gene products of NPHS1 and NEPH1, are podocyte membrane
proteins of the Ig superfamily. Similar to the nephrin knockout, mice lacking NEPH1 show …

Podocytes are significant in establishing the glomerular filtration barrier. Sustained rennin–
angiotensin system (RAS) activation is crucial in the pathogenesis of podocyte injury and …

Autosomal dominant polycystic kidney disease (ADPKD) is typified by the accumulation of
fluid-filled cysts and abnormalities in renal epithelial cell function. The disease is principally …

Morphogenesis of epithelial cells involves processes by which kidney shape and function
are regulated. The lack of in vitro models that are sustainable for longer time periods and …

Polycystic kidneys are caused by an amazingly broad array of genetic mutations and
manipulations. The ciliary hypothesis has evolved as the unifying concept of cystogenesis …

In autosomal dominant polycystic kidney disease (ADPKD), the precise steps leading to cyst
formation and loss of renal function remain uncertain. Pathophysiologic studies have …

Src family kinases (SFKs) belong to nonreceptor protein tyrosine kinases and have been
implicated in the regulation of numerous cellular processes, including cell proliferation …

Every day, human renal tubules process 140 l of glomerular filtrate into 1 l of urine. They
accomplish this by the coordinated function of distinct cell types occupying specific positions …