Mitochondria, with their intricate networks of functions and information processing, are
pivotal in both health regulation and disease progression. Particularly, mitochondrial …

Parkinson disease (PD) is a neurodegenerative disorder marked by the preferential
dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and …

Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson's
disease (PD) and aberrant αSyn is a key pathological hallmark of idiopathic PD. This α …

Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital
functions across diverse cellular processes. Dysfunctions within mitochondria serve as …

Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …

Mutations in GBA1, the gene encoding the lysosomal enzyme β-glucocerebrosidase
(GCase), which cause Gaucher's disease, are the most frequent genetic risk factor for …

Abstract The emerging toxicant N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine
quinone (6PPD-Q) is of wide concern due to its ubiquitous occurrence and high toxicity …

Parkinson's disease (PD) is a growing cause of disability worldwide and there is a critical
need for the development of disease-modifying therapies to slow or stop disease …

Mitochondrial dysregulation, such as mitochondrial complex I deficiency, increased
oxidative stress, perturbation of mitochondrial dynamics and mitophagy, has long been …