The brain plans and executes volitional movements. The underlying patterns of neural
population activity have been explored in the context of movements of the eyes, limbs …

Simple Summary We review advances in the properties of calcium sensors, microscopy, and
data analysis that have brought about the ability to image large contiguous regions of the …

Variation in an animal's behavioral state is linked to fluctuations in brain activity and
cognitive ability. In the neocortex, state-dependent circuit dynamics may reflect …

Understanding how cortical circuits generate complex behavior requires investigating the
cell types that comprise them. Functional differences across pyramidal neuron (PyN) types …

Behavioral states can influence performance of goal-directed sensorimotor tasks. Yet, it is
unclear how altered neuronal sensory representations in these states relate to task …

Motor behaviors are often planned long before execution but only released after specific
sensory events. Planning and execution are each associated with distinct patterns of motor …

The claustrum, a subcortical nucleus forming extensive connections with the neocortex, has
been implicated in sensory selection. Sensory-evoked claustrum activity is thought to …

A surprising finding of recent studies in mouse is the dominance of widespread movement-
related activity throughout the brain, including in early sensory areas. In awake subjects …

Learning of adaptive behaviors requires the refinement of coordinated activity across
multiple brain regions. However, how neural communications develop during learning …

Executive function is susceptible to aging. How aging impacts the circuit-level computations
underlying executive function remains unclear. Using calcium imaging and optogenetic …