Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
[HTML][HTML] Diverse roles of mitochondria in ischemic stroke
Stroke is the leading cause of adult disability and mortality in most develo** and
developed countries. The current best practices for patients with acute ischemic stroke …
developed countries. The current best practices for patients with acute ischemic stroke …
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
INTRODUCTION The emergence of three lethal coronaviruses in< 20 years and the urgency
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies …
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies …
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis
B Zhou, J Zhang, X Liu, H Chen, Y Ai, K Cheng, R Sun… - Cell research, 2018 - nature.com
Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS)
and to participate in different modes of cell death, such as ferroptosis, apoptosis and …
and to participate in different modes of cell death, such as ferroptosis, apoptosis and …
Redox signaling by reactive electrophiles and oxidants
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
Regulation of mitochondrial biogenesis
Although it is well established that physical activity increases mitochondrial content in
muscle, the molecular mechanisms underlying this process have only recently been …
muscle, the molecular mechanisms underlying this process have only recently been …
Mitochondrial protein import: from proteomics to functional mechanisms
Mitochondria contain∼ 1,000 different proteins, most of which are imported from the cytosol.
Two import pathways that direct proteins into the mitochondrial inner membrane and matrix …
Two import pathways that direct proteins into the mitochondrial inner membrane and matrix …
Instant super-resolution imaging in live cells and embryos via analog image processing
Existing super-resolution fluorescence microscopes compromise acquisition speed to
provide subdiffractive sample information. We report an analog implementation of structured …
provide subdiffractive sample information. We report an analog implementation of structured …
Transcriptional control of mitochondrial biogenesis: the central role of PGC-1α
R Ventura-Clapier, A Garnier… - Cardiovascular …, 2008 - academic.oup.com
Although the concept of energy starvation in the failing heart was proposed decades ago,
still very little is known about the origin of energetic failure. Recent advances in molecular …
still very little is known about the origin of energetic failure. Recent advances in molecular …
The role of mitochondria in the pathogenesis of type 2 diabetes
The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …
association of DM with obesity and inactivity indicates an important, and potentially …